Jian Li


Jian Li    Assistant Professor, PI
InstituteSchool of Physical Science and Technology
Research AreaCell-free Protein Synthesis (CFPS), Natural Product Biosynthesis, Synthetic Biology
Contact Info.lijian@@shanghaitech.edu.cn

2017.9-present, Assistant Professor, PI, School of Physical Science and Technology, ShanghaiTech University
2013.12-2017.8, Postdoc, Northwestern University, USA
2007.7-2010.9, Teacher, Anhui Agricultural University, China

2010.10-2013.9, Ph.D., Technische Universit?t Berlin, Germany
2004.9-2007.6, M.S., Anhui Agricultural University, China
2000.9-2004.7, B.S., Anhui Agricultural University, China

Research Interests
1. Cell-free synthetic biology;
2. Development of novel cell-free protein synthesis (CFPS) systems;
3. Natural product biosynthesis and discovery;
4. Novel protein-based biomaterials.

Selected Publications
(*Corresponding author, #Co-first author)

1. Li J, Wang H, Kwon YC, Jewett MC. Establishing a high yielding Streptomyces-based cell-free protein synthesis system. Biotechnology and Bioengineering, 2017, 114, 1343-1353 (Video highlighted)

2. Goering AW#, Li J#, McClure RA, Thomson RJ, Jewett MC, Kelleher NL. In vitro reconstruction of nonribosomal peptide biosynthesis directly from DNA using cell-free protein synthesis. ACS Synthetic Biology, 2017, 6, 39–44

3. Li J, Lawton TJ, Kostecki JS, Nisthal A, Fang J, Rosenzweig AC, Jewett MC. Cell-free protein synthesis enables high yielding synthesis of an active multicopper oxidase. Biotechnology Journal, 2016, 11, 212–218 (Front cover)

4. Moatsou D#, Li J#, Ranji A, Pitto-Barry A, Ntai I, Jewett MC, O’Reilly RK. Self-assembly of temperature-responsive protein-polymer bioconjugates. Bioconjugate Chemistry, 2015, 26, 1890–1899 (Front cover)

5. Li J*, Jaitzig J, Lu P, Süssmuth RD, Neubauer P. Scale-up bioprocess development for production of the antibiotic valinomycin in Escherichia coli based on consistent fed-batch cultivations. Microbial Cell Factories, 2015, 14, 83

6. Li J, Zhao Z, Mo T, Wang L, Li P. Immobilization of aminoacylase on electrospun nanofibrous membrane for the resolution of DL-theanine. Journal of Molecular Catalysis B: Enzymatic, 2015, 116, 24–28

7. Li J*, Jaitzig J, Theuer L, Legala OE, Süssmuth RD, Neubauer P. Type II thioesterase improves heterologous biosynthesis of valinomycin in Escherichia coli. Journal of Biotechnology, 2015, 193, 16–22

8. Li J*, Neubauer P. Escherichia coli as a cell factory for heterologous production of nonribosomal peptides and polyketides. New Biotechnology, 2014, 31, 579–585 (Invited review)

9. Li J, Jaitzig J, Hillig F, Süssmuth RD, Neubauer P. Enhanced production of the nonribosomal peptide antibiotic valinomycin in Escherichia coli through small-scale high cell density fed-batch cultivation. Applied Microbiology and Biotechnology, 2014, 98, 591–601

10. Jaitzig J#, Li J#, Süssmuth RD, Neubauer P. Reconstituted biosynthesis of the nonribosomal macrolactone antibiotic valinomycin in Escherichia coli. ACS Synthetic Biology, 2014, 3, 432–438

11. Li J, Li P, Liu F. Production of theanine by Xerocomus badius (mushroom) using submerged fermentation. LWT-Food Science and Technology, 2008, 41, 883–889

12. Li P, Wan X, Zhang Z, Li J, Shen Z. A novel assay method for theanine synthetase activity by capillary electrophoresis. Journal of Chromatography B, 2005, 819, 81–84

13. Li P, Li J, Wu C, Wu Q, Li J. Synergistic antibacterial effects of β-lactam antibiotic combined with silver nanoparticles. Nanotechnology, 2005, 16, 1912–1917


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