Shengjie Ling


Shengjie Ling    Assistant Professor, PI
InstituteSchool of Physical Science and Technology
Research AreaNatural Structural Materials,Material Biology, Biomateriomics

2004/09-2009/06, B.S., Zhejiang University of Technology, China
2009/09-2014/06, Ph.D., Fudan University, Shanghai, China
2012/11-2013/08, Joint Ph.D. Student, ETH Zurich, Switzerland
2014/09-2017/09, Postdoctoral Associate, MIT and Tufts University, USA
2017/09, Assistant Professor, PI, Shanghaitech University, China

Research Interests
(1)Understanding structure and self-assembly behaviors of recombinant proteins and natural structural materials by synergetic integration of synchrotron characterization, computational modeling and experimental synthesis. 
(2)Developing bioinspired & biomimetic materials, bio-nanomaterials and functional biological materials.

Selected Publications
1. Shengjie Ling, Zhao Qin, Wenwen Huang, Sufeng Cao, David L. Kaplan, Markus J. Buehler. Design and function of biomimetic multilayer water purification membranesScience Advances, 2017, 3, e1601939.

2. Shengjie Ling, Zhao Qin, Chunmei Li, Wenwen Huang, David L. Kaplan, Markus J. Buehler. Polymorphic regenerated silk fibers assembled through bioinspired spinningNature Communications, in press. 

3. Shengjie Ling, Chunmei Li, Kai Jin, David L. Kaplan, Markus J. Buehler. Liquid Exfoliated Natural Silk Nanofibrils: Applications in Optical and Electrical DevicesAdvanced Materials, 2016, 28, 7783-7790. 

4. Shengjie Ling, Kai Jin, David L. Kaplan, Markus J. Buehler. Ultrathin Free-Standing Bombyx mori Silk Nanofibril MembraneNano Letters, 2016, 16, 3795-3800.

5. Shengjie Ling, Chaoxu Li, Jozef Adamcik, Zhengzhong Shao, Xin Chen, Raffaele Mezzenga. Modulating Materials by Orthogonally Oriented β-Strands: Composites of Amyloid and Silk Fibroin FibrilsAdvanced Materials, 2014, 26, 4569-4574.     

6. Shengjie Ling, Qiang Zhang, David L. Kaplan, Fiorenzo Omenetto, Markus J. Buehler, Zhao Qin. Printing of stretchable silk membranes for strain measurementsLab on a Chip, 2016, 16, 2459-2466.

7. Shengjie Ling, Nina Dinjaski, Davoud Ebrahimi, Joyce Y. Wong, David L. Kaplan, Markus J. Buehler.Conformation Transitions of Recombinant Spidroins via Integration of Time-Resolved FTIR Spectroscopy and Molecular Dynamic SimulationACS Biomaterials Science & Engineering, 2016, 2, 1298-1308.

8.Nina Dinjaski, Davoud Ebrahimi, Shengjie Ling (co-first author), Suraj Shah, Markus J. Buehler, David L. Kaplan. Integrated modeling and experimental approaches to control silica modification of design silk-based biomaterialstion. ACS Biomaterials Science & Engineering, 2016, DOI: 10.1021/acsbiomaterials.6b00236.

9.Jin Guo, Chunmei Li, Shengjie Ling, Wenwen Huang, Yin Chen, David L. Kaplan. Multiscale design and synthesis of biomimetic gradient protein/biosilica composites for interfacial tissue engineering.Biomaterials, 145, 44-55.

10.Chunmei Li, Blake Hotz, Shengjie Ling, Jin Guo, Dylan S. Haas, Benedetto Marelli, Fiorenzo Omenetto, Samuel J. Lin, David L. Kaplan. Regenerated silk materials for functionalized silk orthopedic devices by mimicking natural processingBiomaterials, 2016, 110, 24-33.

11. Shengjie Ling, Heyi Liang, Zhao Li, Jinrong Yao, Zhengzhong Shao, Xin Chen. Soy protein-directed one-pot synthesis of gold nanomaterials and their functional conductive devicesJournal of Materials Chemistry B, 2016, 4, 3643-3650.

12. Shengjie Ling, Chaoxu Li, Jozef Adamcik, Suhang Wang, Zhengzhong Shao, Xin Chen, Raffaele Mezzenga. Directed growth of silk nanofibrils on graphene and their hybrid nanocompositesACS Macro Letters, 2014, 3, 146-152;

13. Shengjie Ling, Zeming Qi, Zhengzhong Shao, Xin Chen. Determination of phase behaviour in all protein blend materials with multivariate FTIR imaging techniqueJournal of Materials Chemistry B, 2015, 5, 834-839.

14. Shengjie Ling, Zeming Qi, David P. Knight, Yufang Huang, Lei Huang, Huan Zhou, Zhengzhong Shao, Xin Chen. Insight into the structure of single Antheraea pernyi silkworm fibers using synchrotron FTIR microspectroscopyBiomacromolecules, 2013, 14, 1885-1892.

15. Shengjie Ling, Zeming Qi, David P. Knight, Zhengzhong Shao, Xin Chen. Synchrotron FTIR microspectroscopy of single natural silk fibersBiomacromolecules, 2011, 12, 3344-3349.

16. Shengjie Ling, Zeming Qi, David P. Knight, Zhengzhong Shao, Xin Chen. FTIR imaging, a useful method for studying the compatibility of silk fibroin-based polymer blends.Polymer Chemistry, 2013, 4, 5401-5406.

17. Shengjie Ling, Li Zhou, Wen Zhou, Zhengzhong Shao, Xin Chen. Conformation transition kinetics and spinnability of regenerated silk fibroin with glycol, glycerol and polyethylene glycolMaterials Letters, 2012, 81, 13-15.

18. Shengjie Ling, Zeming Qi, Benjamin Watts, Zhengzhong Shao, Xin Chen. Structural determination of protein-based polymer blends with a promising tool--Combination of FTIR and STXM spectroscopic imagingPhysical Chemistry Chemical Physics, 2014, 16, 7741-7748.

19. Shengjie Ling, Zhengzhong Shao, Xin Chen. Application of Synchrotron FTIR Imaging for Cells.Progress in Chemistry, 2014, 26, 178-192.

20.Chun-Teh Chen, Francisco J. Martin-Martinez, Shengjie Ling, Zhao Qin, Markus J. Buehler. Nacre-inspired design of graphene oxide—polydopamine nanocomposites for enhanced mechanical properties and multi-functionalitiesNano futures, 2017, 1, 011003. 

21. Shengjie Ling, Yufang Huang, Lei Huang, Zhengzhong Shao, Xin Chen. Application of Synchrotron FTIR Microspectroscopy and Mapping in Analytical Chemistry. Progress in Chemistry, 2013, 25, 821-830.

22.Yingxin Liu, Shengjie Ling, Suhang Wang, Xin Chen, Zhengzhong Shao. Thixotropic silk nanofibril-based hydrogel with extracellular matrix-like structureBiomaterials Science, 2014, 10, 1338-1342.

23.Jingxin Zhu, Wenwen Huang, Qiang Zhang, Shengjie Ling, Ying Chen, David L. Kaplan. Thixotropic silk nanofibril-based hydrogel with extracellular matrix-like structureMaterials, 2016, 9, 211.

24.Xin Chen, Heifei Cai, Shengjie Ling, Zhengzhong Shao, Yufang Huang. Conformation transition of Bombyx mori silk protein monitored by time-dependent Fourier Transform Infrared (FT-IR) Spectroscopy: effect of organic solventApplied Spectroscopy, 2012, 66, 696-699.

25.Nina Dinjaski, Davoud Ebrahimi, Zhao Qin, Jodie E.M. Giordano, Shengjie Ling, Markus J. Buehler, David L. Kaplan. Predicting rates of in vivo degradation of recombinant spider silk proteinsJournal of Tissue Engineering and Regenerative Medicine, DOI: 10.1002/term.2380.

1. Xin Chen, Shengjie Ling, Zhengzhong Shao. CN 103757729 A
2. Zhengzhong Shao, Yinxin Liu, Shengjie Ling, Xin Chen. CN104017374 B


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